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2015 · Background A substantial fraction of all American healthcare expenditures are potentially wasted, and practices that are not evidence-based could contribute to such waste.0’’ to 14. Prolongations of both the PT and the aPTT signal a problem with acquisition of a . If PT, aPTT, and platelet count are normal in a patient with a history of mucocutaneous bleeding, then primary hemostasis should be investigated (eg, with the platelet function analyzer PFA-100 [Dade Behring, Inc, Deerfield, Ill], which can also screen for vWD). However it cannot monitor therapy with newer "low molecular weight heparin" (LMWH). A similar but more subtle problem might arise if the patient's hematocrit is unusually high, typically ≥55%.
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